Specialist/Senior Pharmacometrician – Translational & Clinical Development

About the role

Ascendis Pharma is seeking a hands‑on Specialist or Senior Specialist Pharmacometrician to lead model‑informed drug development across translational and clinical programs, primarily in rare diseases.

Key responsibilities

• Develop model‑informed strategies for translational and clinical‑stage projects, influencing trial design, dose selection and lifecycle decisions.
• Shape regulatory strategy and represent pharmacometrics in global health‑authority interactions.
• Perform population PK/PD modeling, simulation, exposure‑response analysis and quantitative benefit‑risk assessment.
• Document and report analyses to meet internal quality standards and regulatory submission requirements.
• Strengthen departmental methods through peer reviews, knowledge sharing and workflow improvements.

Required profile

• PhD, MSc or equivalent in pharmacometrics, pharmaceutical sciences, pharmacokinetics, mathematics, engineering or a related quantitative discipline.
• Hands‑on experience with NONMEM and R for population PK/PD model development and simulation.
• Strong programming and documentation skills for regulatory‑grade analyses.
• Experience with translational and clinical‑stage analyses, including dose selection and trial‑design questions.

Required skills

• NONMEM
• R
• LaTeX
• Git